Simply enter your dissolution data and get accurate F1 and F2 values INSTANTLY.
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Instant Access. No software installation required
Who Is This For?
This tool is built for:
✓ Pharmaceutical analytical scientists comparing dissolution profiles
✓ Pharmaceutical analytical scientists performing f2 calculations for regulatory submissions
✓ Anyone who needs accurate f1 and f2 results without building formulas from scratch
If you’ve ever spent more than 10 minutes double-checking a formula in a plain Excel sheet — or worried you had the wrong parentheses in your f2 formula — this tool was built for you.
Simply enter your raw data in the yellow input fields
Use the automatic timepoint exclusion feature to follow the 85% rule as per FDA guidance, or take full control by manually selecting timepoints to include or exclude.
Everything is handled inside Excel — no internet connection required, no data uploaded anywhere, no new software to learn.
Try It Before You Buy
Not ready to commit? Start with the free trial.
Sign up with your email and we’ll send you a free trial version of the calculator. The trial gives you limited access so you can explore the tool, test it with your own data, and see how it fits your workflow — before making any decision.
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Frequently Asked Questions
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The calculator works with Excel 2016 and later, including Microsoft 365. It is not compatible with Google Sheets.
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The calculator supports up to 12 time points and up to 12 replicates per time point, in line with FDA and EMA guidance.
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The free trial gives you limited 24-hour access to explore the tool and test it with your data. The full version includes lifetime access, complete functionality, and access to validation documentation of the tool.
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Yes. The calculator runs entirely within Excel on your own computer. No data is uploaded, shared, or stored externally.
Ready to stop second-guessing your f2 formula?
Try the Dissolution Excel add-in for free today.
f1 and f2 Values Calculator for Dissolution
Quickly determine values for f1 difference and f2 similarity factors used in dissolution testing to compare a reference batch with a test batch.
Eliminate fear of complex formulas and report results with confidence.
Easy to follow step-by-step instructions
100% transparency on calculations for reviews and audits
Formulas locked for editing to maintain data integrity
Full refund within 30 days of purchase, no questions asked, if the template does not meet your satisfaction
Excel in Science — Validated Excel Tools for Pharmaceutical Analysis
f1 and f2 Values Calculator for Dissolution
EARLY ACCESS PRICING
$899/year
Price: $699.00/year
Save $200 — Early Access Offer
(Full refund within 30 days of purchase, no questions asked, if the template does not meet your satisfaction)
Determine values for f1 difference and f2 similarity factors used in dissolution testing. Check out this article on how it works.
f1 and f2 Values Calculator for Dissolution
Quickly determine values for f1 difference and f2 similarity factors used in dissolution testing to compare a reference batch with a test batch.
Eliminate fear of complex formulas and report results with confidence.
Easy to follow step-by-step instructions
100% transparency on calculations for reviews and audits
Formulas locked for editing to maintain data integrity
Full refund within 30 days of purchase, no questions asked, if the template does not meet your satisfaction
The Problem with Manual f1/f2 Calculations
Writing f1 and f2 formulas manually in an Excel sheet looks straightforward. In practice, there are at least four ways to get the wrong answer.
Misplaced or missed parentheses in the formula that will result to a completely different result
Forgetting to exclude time points where Rt > 85% (the 85% rule)
Rounding values between different steps in the calculation
No CV check, so non-qualifying data gets included without warning
The troubling part: Excel produces a number either way. You won’t always know when something is wrong.
What the Calculator Does
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